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Sad-ness and anger—this Janus of feeling—these two sides of the human experi-ence of loss, propel us to search and to polish the final tasks required of allreflective animals—to love, to hope, to make sense, to forgive, to reconcile, toaccept, to summon our final message. Narratives are addition-ally continually reshaped and are almost infinitely flexible in their abilityto adapt to new situations. Achatz MIW, Olivier M, Le Calvez F et al (2007) The TP53 mutation, R337H, is associatedwith Li-Fraumeni and Li-Fraumeni-like syndromes in Brazilian families.

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